Antifungal copyrine alkaloids: crystal structure of 3-methylsampangine |
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| Authors: | John R. Peterson Jordan K. Zjawiony Alice M. Clark Charles D. Hufford Robin D. Rogers |
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| Affiliation: | (1) Department of Pharmacognosy and the Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, 38677 University, Mississippi;(2) Present address: Panlabs, Inc., 11804 North Creek Parkway South, 98011 Bothell, Washington;(3) Department of Chemistry, Northern Illinois University, 60115 DeKalb, Illinois |
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| Abstract: | 3-Methylsampangine, C16H10N2O, crystallizes in the monoclinic space group P21/c witha=7.260(3),b=10.697(5),c=15.342(6) Å, and  =102.69(4). All nonhydrogen atoms of this potent antifungal agent are planar to within 0.082 Å. The title compound exhibits potentin vitro antifungal activity againstC. neoformans, C. albicans andA. fumigatus. |
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| Keywords: | Antifungal alkaloids 3-methylsampangine crystal structure |
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