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New hydroperoxybriarane diterpenoids from the octocoral Briareum violaceum
Authors:Jia-Wen Yao  Wei-Chiung Chi  Jing-Hao Xu  Gene-Hsiang Lee  Michael Y. Chiang  Bo-Rong Peng  Nai-Cheng Lin  Chiung-Chin Hu  Lee-Shing Fang  Guo-Qiang Li  Yu-Chia Chang  Tsong-Long Hwang  Ping-Jyun Sung
Affiliation:1. Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, Taiwan;2. National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan;3. Department of Food Science, National Quemoy University, Kinmen 89250, Taiwan;4. Instrumentation Center, National Taiwan University, Taipei 10617, Taiwan;5. Department of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan;6. Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 80708, Taiwan;7. Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan;8. Doctoral Degree Program in Marine Biotechnology, Academia Sinica, Taipei 11529, Taiwan;9. Center for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung 83347, Taiwan;10. Super Micro Mass Research and Technology Center, Cheng Shiu University, Kaohsiung 83347, Taiwan;11. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China;12. Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao 266235, China;13. Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan;14. Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan;15. Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 33302, Taiwan;p. Department of Anaesthesiology, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan;q. Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan;r. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40447, Taiwan;s. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan;t. Research Center for Natural Products and Drug Development, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Abstract:A known briarane, brianthein W (1), along with four new hydroperoxybriaranes, briaviolides R–U (25), have been obtained from the octocoral Briareum violaceum. The absolute configuration of 1 was determined by X-ray analysis for the first time and the structures of briaranes 25 were established by spectroscopic methods. Bioactivity study showed that briarane 3 decreased the production of superoxide anions from human neutrophils.
Keywords:Briareum violaceum  Briaviolide  Brianthein W  Superoxide anion
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