An improved practical Pd/C‐catalyzed Sonogashira cross‐coupling reaction for the synthesis of liquid crystals of trans‐cyclohexyltolans |
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Authors: | Hongyong Shang Ruimao Hua Qingwei Zheng Jianli Zhang Xiao Liang Qiming Zhu |
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Institution: | 1. Department of Chemistry, Tsinghua University, Beijing 100084, China;2. Shijiazhuang (Developed Zone) Yongsheng Huatsing Liquid Crystal Co. Ltd, Shijiazhuang 050091, China |
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Abstract: | An improved practical synthesis of liquid crystals of trans‐cyclohexyltolans by Sonogashira cross‐coupling reaction of 1‐iodo‐4‐(trans‐4‐alkylcyclohexyl)benzene with aromatic terminal alkynes in the presence of Pd/C (palladium on activated carbon) as low as 0.03 mol% of Pd and CuI (2 mol%) in a mixture solvent of acetone–water (5:2 in volume) is described. The liquid crystals could be obtained in high yields as a solid with excellent purity by simple filtration, and the filtrate could be reused several times while still retaining high catalytic activity. Copyright © 2010 John Wiley & Sons, Ltd. |
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Keywords: | Pd/C cuprous iodide cross‐coupling reaction cyclohexyltolans liquid crystals |
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