Two novel diorganotin phosphonic diamides: syntheses,crystal structures,spectral properties and in vitro antibacterial studies |
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| Authors: | Khodayar Gholivand Sedigheh Farshadian Zahra Hosseini Khosro Khajeh Neda Akbari |
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| Affiliation: | 1. Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, PO Box 14115‐175, Tehran, Iran;2. Department of Biochemistry and Biophysics, Faculty of Sciences, Tarbiat Modares University, Tehran, Iran |
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| Abstract: | Two diorganotin complexes with general formulae SnCl2(CH3)2[C6H5P(O)(NHCH(CH3)2)2]2 ( 1 ) and SnCl2(CH3)2[C6H5P(O) (NHC(CH3)3)2] ( 2 ) were prepared by the addition of one equivalent SnCl2Me2 to two equivalents of PhP(O)(NHiPr)2 and PhP(O)(NHtBu)2, respectively. The compounds were characterized by elemental analysis, IR and multinuclear NMR (1H, 13C, 31P and 119Sn) spectroscopy. The crystal structures of the complexes were determined by X‐ray single crystal analysis, which revealed that complex 1 has a distorted octahedral geometry and complex 2 has a distorted trigonal bipyramidal structure with non‐equivalent chlorine atoms. Preliminary antibacterial tests of the compounds against Gram‐positive and ‐negative bacteria were carried out using the filter paper disk method and chloroamphenicol was used as standard for comparison. Copyright © 2010 John Wiley & Sons, Ltd. |
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| Keywords: | phosphonic diamide diorganotin NMR X‐ray structures antibacterial activity |
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