Palladium‐mediated synthesis of novel nimesulide derivatives |
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| Authors: | Shylaprasad Durgadas Vijay kumar Chatare Khagga Mukkanti Sarbani Pal |
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| Institution: | 1. J N T University, Kukatpally, Hyderabad 500072, India;2. MSN Pharmachem Pvt. Ltd, Plot No. 212/A,B,C,D, APIICL, Phase‐II, Pashamylaram, Patancheru (M), Medak District 502 307, Andhra Pradesh, India;3. Department of Chemistry, MNR Degree and PG College, Kukatpally, Hyderabad 500 072, India |
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| Abstract: | Synthesis of a series of compounds structurally related to the anti‐inflammatory agent nimesulide has been accomplished via Pd‐catalyzed C? C bond forming reactions. Thus 4‐iodo derivative, prepared from nimesulide, participated in Sonogashira (copper‐free), Heck and Suzuki coupling reactions to afford the corresponding alkynyl, alkenyl and aryl substituted products. Some of the compounds synthesized were tested for anti‐inflammatory activities in vivo. Copyright © 2010 John Wiley & Sons, Ltd. |
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| Keywords: | nimesulide anti‐inflammatory C?C bond palladium alkyne alkene boronic acid |
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