Heck coupling reaction using monomeric ortho‐palladated complex of 4‐methoxy‐ benzoylmethylenetriphenylphosphorane under microwave irradiation |
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| Authors: | Abdol R. Hajipour Kazem Karami Ghazal Tavakoli |
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| Affiliation: | 1. Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, I. R. Iran;2. Department of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, WI 53706‐1532, USA |
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| Abstract: | The activity of [Pd(C6H4CH2 NH2‐κ2‐C‐N)PPh3MOBPPY]OTf complex, A (MOBPPY = 4‐methoxybenzoylmethylenetriphenyl‐ phosphoraneylide), was investigated in the Heck–Mizoroki C? C cross‐coupling reaction under conventional heating and microwave irradiation conditions. The complex is an active and efficient catalyst for the Heck reaction of aryl halides. The yields were excellent using a catalytic amount of [Pd(C6H4CH2 NH2‐κ2‐C‐N)PPh3MOBPPY]OTf complex in N‐methyl‐2‐pyrrolidinone (NMP) at 130 °C and 600 W. In comparison to conventional heating conditions, the reactions under microwave irradiation gave higher yields in shorter reaction times. Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd. |
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| Keywords: | orthopalladate Heck reaction catalyst microwaves |
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