Zn(OTf)2-catalyzed,microwave-promoted synthesis of 2-substituted 5-methyloxazoles from propargylic amides |
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| Authors: | Alexander Safrygin Dmitry Dar&#x;in Alexei Lukin Anna Bakholdina Alexander Sapegin Mikhail Krasavin |
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| Institution: | 1. Saint Petersburg State University, Saint Petersburg 199034, Russian Federation;2. Lomonosov Institute of Fine Chemical Technologies, MIREA – Russian Technological University, Moscow 119571, Russian Federation |
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| Abstract: | The versatile conversion of propargylic amides to the respective 2-substituted 5-methyloxazoles was efficiently catalyzed by Zn(OTf)2 (5?mol%) under microwave irradiation in toluene. The method was applicable to a wide range of aliphatic, aromatic and heteroaromatic propargylic amides and thus represents a useful method which is complementary to the existing metal-catalyzed protocols, considering the ready availability of Zn(OTf)2. |
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| Keywords: | Propargylic amides Cyclization Zn(II) triflate Oxazoles |
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