Palladium‐catalyzed cyanation reaction of aryl halides using K4[Fe(CN)6] as non‐toxic source of cyanide under microwave irradiation |
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| Authors: | Abdol R Hajipour Kazem Karami Azadeh Pirisedigh |
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| Institution: | 1. Department of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, WI 53706‐1532, USA;2. Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, I. R. Iran |
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| Abstract: | An efficient method for preparation of aryl nitriles—using Pd{C6H2(CH2CH2 NH2)‐(OMe)2,3,4} (µ‐Br)]2 complex as an efficient catalyst and K4Fe(CN)6] as a green cyanide source—from aryl bromides, aryl iodides and aryl chlorides under microwave irradiation has been reported. This complex has been demonstrated to be an active and efficient catalyst for this reaction. Using a catalytic amount of this synthesized palladium complex in DMF at 130 °C led to production of the cyanoarenes in excellent yields in short reaction times. Copyright © 2010 John Wiley & Sons, Ltd. |
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| Keywords: | K4[Fe(CN)6] catalyst cyanation reaction |
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