Enantioselective deprotonation reactions using polymer-supported chiral magnesium amide bases |
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| Authors: | Henderson K W Kerr W J Moir J H |
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| Institution: | Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, Scotland, UK G1 1XL. |
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| Abstract: | Novel and readily accessible polymer-supported chiral magnesium amide reagents have been prepared and shown to be effective in the asymmetric deprotonation of a series of prochiral cyclohexanones, affording good to excellent levels of both conversion and enantiomeric ratio (up to 93:7); the Merrifield-based chiral amine species has been shown to be readily recyclable. |
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