Universal hybridization using LNA (locked nucleic acid) containing a novel pyrene LNA nucleotide monomer |
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| Authors: | Babu B R Wengel J |
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| Institution: | Department of Chemistry, University of Southern Denmark, DK-5230 Odense M, Denmark. |
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| Abstract: | A novel pyrene LNA nucleotide monomer is shown to mediate universal hybridization when incorporated into a DNA strand or a 2'-OMe-RNA/LNA chimeric strand. For the latter, high-affinity universal hybridization without compromising the base-pairing selectivity of bases neighbouring the universal pyrene LNA nucleotide monomer is documented. |
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