Perspectives in paramagnetic NMR of metalloproteins |
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Authors: | Bertini Ivano Luchinat Claudio Parigi Giacomo Pierattelli Roberta |
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Institution: | Magnetic Resonance Center, University of Florence, Via L. Sacconi 6, 50019, Sesto Fiorentino, (FI), Italy. ivanobertini@cerm.unifi.it |
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Abstract: | NMR experiments and tools for the characterization of the structure and dynamics of paramagnetic proteins are presented here. The focus is on the importance of (13)C direct-detection NMR for the assignment of paramagnetic systems in solution, on the information contained in paramagnetic effects observed both in solution and in the solid state, and on novel paramagnetism-based tools for the investigation of conformational heterogeneity in protein-protein complexes or in multi-domain proteins. |
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