One-pot Synthesis of 1,8-Dioxo-decahydroacridine Derivatives in Aqueous Media |
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| Authors: | BALALAIE Saeed CHADEGANI Fatemeh DARVICHE Fatemeh BIJANZADEH Harnid Reza |
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| Affiliation: | 1. Peptide Chemistry Research Group,K.N.Toosi University of Technology,15875-4416,Tehran,Iran
2. Department of Chemistry,Tarbiat Modares University,14115-175,Tehran,Iran |
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| Abstract: | A new and efficient method for the synthesis of 1,8‐dioxo‐9‐aryl‐decahydroacridine derivatives was developed via a one‐pot three component reaction of dimedone, aromatic aldehydes and ammonium acetate in the presence of ammonium chloride, or Zn(OAc)2·2H2O or L‐proline separately in water in the short period of time and high yields. |
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| Keywords: | 1,8-dioxo-9-aryl-decahydro-acridine derivative Domino Knoevenagel-Michael reaction aqueous media one-pot three component reaction ammonium chloride Zn(Oac)2·2H2O L-proline |
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