| Solid Phase Synthesis of Ethyl β-Substituted Indolepropionates |
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| 引用本文： | 刘占祥 阮秀秀 黄宪. Solid Phase Synthesis of Ethyl β-Substituted Indolepropionates[J]. 中国化学, 2003, 21(11): 1497-1500. DOI: 10.1002/cjoc.20030211121 |
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| 作者姓名： | 刘占祥 阮秀秀 黄宪 |
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| 作者单位： | DepartmentofChemistry,ZhejiangUniversity（XixiCampus）,Hangzhou,Zhejiang310028,China |
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| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 0 0 72 0 3 2 ) |
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| 摘 要： | A facile solid phase synthesis of ethyl β-substituted indolepropionates is reported. Condensation between indole, polymer-supported cyclic malonic acid ester and aldehyde yielded the trimolecular adducts, which was cleaved by pyridine/EtOH to release the final products in good yield with high purity.
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| 关 键 词： | 固相合成 乙基β-取代吲哚丙酸酯 吲哚 药物研究 多组分反应 Meldrum’s酸 |
Solid Phase Synthesis of Ethyl β‐Substituted Indolepropionates |
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| LIU,Zhan-Xiang a RUAN,Xiu-Xiu HUANG,Xian,a,b a. Solid Phase Synthesis of Ethyl β‐Substituted Indolepropionates[J]. Chinese Journal of Chemistry, 2003, 21(11): 1497-1500. DOI: 10.1002/cjoc.20030211121 |
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| Authors: | LIU Zhan-Xiang a RUAN Xiu-Xiu HUANG Xian a b a |
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| Affiliation: | Xixi Campus |
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| Abstract: | A facile solid phase synthesis of ethyl β‐substituted indolepropionates is reported. Condensation between indole, polymer‐supported cyclic malonic acid ester and aldehyde yielded the trimolecular adducts, which was cleaved by pyridine/EtOH to release the final products in good yield with high purity. |
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| Keywords: | solid phase synthesis Meldrum's acid indole indolepropionic ester multicomponent reactions |
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