| 磷酸酯-碳酸酯共聚物的合成及其微球释药性能研究 |
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| 引用本文： | 柯天一,卓仁禧.磷酸酯-碳酸酯共聚物的合成及其微球释药性能研究[J].高等学校化学学报,1998,19(8):1335-1338. |
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| 作者姓名： | 柯天一 卓仁禧 |
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| 作者单位： | 武汉大学化学院, 教育部生物医用高分子材料开放实验室, 武汉, 430072 |
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| 摘 要： | 在光气、二氯磷酸溴乙酯和双酚A反应后,用三甲胺季铵化侧链,得到了4种两亲性磷酸酯-碳酸酯共聚物.用IR、1HNMR及元素分析表征了共聚物,测量了水接触角和Mn,研究了其在pH为7.4磷酸盐缓冲溶液中的降解性能.制得了共聚物微球,并研究了微球的形态、粒径及其对抗肿瘤药物5-Fu的释放性能.
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| 关 键 词： | 两亲性磷酸酯－碳酸酯共聚物 微球 体外降解 |
| 收稿时间： | 1997-07-14 |
Synthesis of Amphiphilic Phosphate-Carbonate Copolymers and Drug Release Property of Their Microspheres |
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| KE Tian-Yi,ZHUO Ren-Xi.Synthesis of Amphiphilic Phosphate-Carbonate Copolymers and Drug Release Property of Their Microspheres[J].Chemical Research In Chinese Universities,1998,19(8):1335-1338. |
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| Authors: | KE Tian-Yi ZHUO Ren-Xi |
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| Institution: | College of Chemistry, Laboratory of Biomedical Polymer Materials of the Ministry of Education, Wuhan University, Wuhan, 430072 |
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| Abstract: | Four amphiphilic phosphate carbonate copolymers were synthesized by polycondensation of bisphenol A, phosgene and 2-bromoethyl phosphorodichloridate, and then quaternized with trimethylamine. The copolymers obtained were characterized by IR, 1HNMR and elemental analysis. Average molecular weight(Mn) and water contact angle were measured. The in vitro degradation of copolymers was studied in pH7.4 phosphate buffer solution at 37 ℃. Microspheres of these coploymer were prepared, their morphology, size and in vitro drug release of 5-Fu were also investigated. |
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| Keywords: | Amphiphilic phosphate carbonate copolymer Microsphere In vitro degradation |
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