Unresolvable long range spin–spin coupling as a source of systematic error in proton NMR total bandshape analysis

Unresolvable long range spin-spin coupling which is not explicitly taken into account in total NMR bandshape analysis is demonstrated to be a potentially important source of systematic error, leading to ΔH^≠ and δS^≠ values incorrect by c. 1 kcal/mol and 2 to 4 cal/(mol K), respectively.