Modelling of ultrasound therapeutic heating and numerical study of the dynamics of the induced heat shock response |
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| Institution: | 1. Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawińskiego 5B, 02-106 Warsaw, Poland;2. Department of Information Technologies, Åbo Akademi University & Turku Centre for Computer Science, Joukahaisenkatu 3-5A, FIN-20520 Turku, Finland;1. Division of Anatomy, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania;2. Division of Histology, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania;3. “Victor Babe?” National Institute of Pathology, Bucharest, Romania;4. Division of Anatomy, Faculty of Medicine, “Victor Babe?” University of Medicine and Pharmacy, Timi?oara, Romania;5. Department of Cellular and Molecular Biology, National Institute of Research and Development for Biological Sciences, Bucharest, Romania;6. Department II of Surgical Clinical Divisions, Faculty of Medicine, “Ovidius” University, Constan?a, Romania;1. Center for Lasers and Photonics, Indian Institute of Technology Kanpur, Kanpur, 208016, India;2. Department of Physics, Indian Institute of Technology Kanpur, Kanpur, 208016, India |
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| Abstract: | In this presentation we consider hyperthermia, a procedure of raising the temperature above 43 °C, as a treatment modality. To this purpose, a numerical model of in vivo soft tissue ultrasound heating is proposed by extending a previously presented in vitro model. Based on the numerical simulations, a heating scheme satisfying some constraints related to potential clinical applications is established, and the resulting temperature time-course profile is composed with the temperature-dependent protein denaturation formula of a recently published mathematical model for the eukaryotic heat shock response. The obtained simulation results of the combined models are discussed in view of potential application of ultrasound soft tissue heating in clinical treatment. |
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