Fractional and continuous wavelet transforms for the simultaneous spectral analysis of a binary mixture system |
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| Institution: | 1. Department of Pediatric Radiology, Childrens Hospital of Pittsburgh of University of Pittsburgh Medical Center and University of Pittsburgh School of Medicine, Pittsburgh, PA;2. Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA;3. Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA;4. Department of Pediatrics, Division of Cardiology, Childrens Hospital of Los Angeles, Los Angeles, CA;5. Division of Pediatric Cardiology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA;6. Cardiac Intensive Care Division, University of Pittsburgh School of Medicine, Pittsburgh, PA;7. Division of Pediatric Cardiothoracic Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA |
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| Abstract: | A combined application of the fractional wavelet transform-continuous wavelet transform to the quantitative resolution of the overlapping signals of olmesartan modoxomil and hydrochlorothiazide in a binary mixture was presented. In this work the recorded absorption signals of two compounds in the range 4–12 μg/mL olmesartan and 2–10 μg/mL hydrochlorothiazide were processed by the fractional transform approach and with the continuous wavelet transform, respectively. The proposed combined complex signal analysis method was validated by analyzing the synthetic binary mixtures of the related compound. By analyzing the statistical parameters we conclude that the new approach is suitable to be used for the quality control of the commercial samples of compounds. |
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