| Synthesis and Cytotoxic Activity of Novel Water-soluble Prodrugs of Combretastatin A-4 |
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| 引用本文： | Zhi Quart YONG Xiao Ping XU Ying Chun CHEN Xu BAO Ling Ling WENG Hu ZHENG. Synthesis and Cytotoxic Activity of Novel Water-soluble Prodrugs of Combretastatin A-4[J]. 中国化学快报, 2006, 17(1): 23-26 |
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| 作者姓名： | Zhi Quart YONG Xiao Ping XU Ying Chun CHEN Xu BAO Ling Ling WENG Hu ZHENG |
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| 作者单位： | Zhi Quan YONG，Xiao Ping XU，Ying Chun CHEN，Xu BAO，Ling Ling WENG*，Hu ZHENG Department of Medicinal Chemistry，West China School of Pharmacy，Sichuan University，Chengdu 610041 |
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| 基金项目： | Acknowledgment The project sponsored by SRF for R0CS, SEM. We are also grateful for the financial support from the grant of Sichuan University. |
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| 摘 要： | Combretastatin A-4 (CA4) 1 is a natural product isolated from the bark of a South African tree Combretum caffrum1-3. This substance is a potent antimitotic agent and can strongly inhibit the polymerization of tubulin by binding to the colchicine-binding s…
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| 关 键 词： | 合成 细胞毒素活性 水溶前药 磷酰基胆碱 Combretastafin A-4 分离 |
| 收稿时间： | 2005-05-18 |
Synthesis and Cytotoxic Activity of Novel Water-soluble Prodrugs of Combretastatin A-4 |
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| Zhi Quan YONG,Xiao Ping XU,Ying Chun CHEN,Xu BAO,Ling Ling WENG,Hu ZHENG. Synthesis and Cytotoxic Activity of Novel Water-soluble Prodrugs of Combretastatin A-4[J]. Chinese Chemical Letters, 2006, 17(1): 23-26 |
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| Authors: | Zhi Quan YONG Xiao Ping XU Ying Chun CHEN Xu BAO Ling Ling WENG Hu ZHENG |
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| Abstract: | |
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| Keywords: | Combretastatin A-4 cytotoxicity phosphoryl choline water-soluble prodrug. |
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