Design and synthesis of 4-(1-(4-chlorobenzyl)-2,3-dioxoindolin-5-yl)-1 -(4-substituted/unsubstituted benzylidene) semicarbazide:Novel agents with analgesic,anti-inflammatory and ulcerogenic properties |
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| Authors: | Chinnasamy Rajaram Prakasha Sundararajan Rajab Govindaraj Saravananc a |
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| Affiliation: | Department of Medicinal Chemistry, DCRM Pharmacy College, JNTUH, Andhra Pradesh, India ; Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, GITAM University, Vizag, Andhra Pradesh, India ; Medicinal Chemistry Research Laboratory, Bapatla College of Pharmacy, Bapatla- 522 101, Andhra Pradesh, India |
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| Abstract: | A new series of isatin semicarbazide derivatives(7a-7j) were synthesized and characterized by spectroscopic means and elemental analysis.Analgesic and anti-inflammatory screening was performed using tail-flick technique and the carrageenan-induced foot paw edema test respectively.The ulcerogenicity was also determined for all the compounds.Some of the compounds showed moderate enhancement of the activity.Among the synthesized derivatives,compound 7d showed higher analgesic, antiinflammatory and one-third of ulcer index of the reference drug. |
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| Keywords: | Isatin Anti-nociceptive Schiff base Ulcerogenicity |
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