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Design,Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins |
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| Authors: | Dr. Vinod Khatri Dr. Badri Parshad Prof. Ashok K. Prasad Dr. Sumati Bhatia |
| Affiliation: | 1. Institute for Chemistry and Biochemistry, Freie University Berlin, Takustr. 3, Berlin, 14195 Germany Department of Chemistry, TDL Govt. College for Women, Murthal, 131027 Sonipat, Haryana, India Contribution: Writing - original draft (lead);2. Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129 USA Contribution: Writing - original draft (supporting);3. Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, 110007 India Contribution: Writing - review & editing (supporting);4. Institute for Chemistry and Biochemistry, Freie University Berlin, Takustr. 3, Berlin, 14195 Germany |
| Abstract: | In the last decades, various efforts have been made to synthesize optimal glycotripods for targeting trimeric glycoproteins like asialoglycoprotein receptor, hemagglutinin, and langerin. All these trimeric glycoproteins have sugar binding pockets which are highly selective for a particular carbohydrate ligand. Optimized glycotripods are high affinity binders and have been used for delivering drugs or even applied as drug candidates. The selection of the tripodal base scaffold together with the length and flexibility of the linker between the scaffold and sugar residue, as important design parameters are discussed in this review. |
| Keywords: | Carbohydrates Drug delivery Glycotripod Hemagglutinin Lectin binder |