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Total Synthesis of (E/Z) des-Hydroxy Triticone A and B |
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| Authors: | Sunil Dattatray Chakave Shrikant Shete Dr Sandeep Reddy Kandukuri Dr Mark Montgomery Dr Bhanu N Manjunath Dr Ravindra Punjaji Sonawane |
| Institution: | 1. Syngenta Biosciences Private Limited Santa Monica Works, Corlim, Goa, 403110 India
Department of Chemistry, Mangalore University, Mangalagangothri, 576119 India;2. Syngenta Biosciences Private Limited Santa Monica Works, Corlim, Goa, 403110 India;3. Syngenta Jealotts Hill International Research Centre, Bracknell, Berkshire, RG42 6EY UK;4. Syngenta Crop Protection AG, Schaffhauserstrasse 101, 4332 Stein AG, Switzerland |
| Abstract: | The first total synthesis of des-hydroxy triticone A and B was achieved in 12 steps. The highly chemoselective, base mediated iodolactamization of olefins with N-OMe amide motif is a key highlight of the synthesis. |
| Keywords: | crop protection iodolactamization natural products spirocycles triticones |