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Synthesis of Dibenzo[b,e]azepin-6(11H)-ones via a Sequential Ugi-4CR and Sulfur Ylide-Mediated Rearrangement Reaction |
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| Authors: | Dr. Han-Han Kong Dr. Long Zhao Dr. Hong-Ling Pan Prof. Ming-Wu Ding |
| Affiliation: | 1. National Key Laboratory of Green Pesticide, Hubei International Scientific and Technological, Cooperation Base of Pesticide and Green Synthesis, Central China Normal University, Wuhan, 430079 P. R. China Key Laboratory of Inorganic Nonmetallic, Crystalline and Energy Conversion Materials, College of Materials and Chemical Engineering, China Three Gorges University, Yichang, 443002 Hubei, P. R. China;2. National Key Laboratory of Green Pesticide, Hubei International Scientific and Technological, Cooperation Base of Pesticide and Green Synthesis, Central China Normal University, Wuhan, 430079 P. R. China |
| Abstract: | A new one-pot preparation of dibenzo[b,e]azepin-6(11H)-one by a sequential Ugi-4CR and sulfur ylide-mediated rearrangement reaction has been developed. A series of polysubstituted dibenzo[b,e]azepin-6(11H)-ones were obtained in 69–84 % yields from readily available sulfonium salts, 2-aminophenyl ketones, aldehydes and isocyanides in the presence of DBU. |
| Keywords: | cyclization dibenzo[b,e]azepin-6(11H)-one rearrangement reaction sulfur ylide ugi reaction |