On the cyclic deformation behavior,fracture properties and cytotoxicity of silicone-based elastomers for biomedical applications |
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| Institution: | 1. ETH Zurich, Institute for Mechanical Systems, 8092 Zürich, Switzerland;2. Empa, Swiss Federal Laboratories for Materials Science and Technology, 8600 Dübendorf, Switzerland;3. ETH Zurich, Laboratory for Thermodynamics in Emerging Technologies, 8092 Zürich, Switzerland;1. Center for Advanced Materials, Qatar University, PO Box 2713, Doha, Qatar;2. Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského nám. 2, 162 06 Praha, Czechia;1. Department of Mechanical Engineering, Faculty of Engineering of Bilbao, University of the Basque Country (UPV/EHU), Rafael Moreno “Pitxitxi” 2-3, 48013 Bilbao, Spain;2. Department of Mining, Metallurgy and Science of Materials, Faculty of Engineering of Bilbao, University of the Basque Country (UPV/EHU), Rafael Moreno “Pitxitxi” 2-3, 48013 Bilbao, Spain;3. Materials Testing and Simulation, Leartiker (Lea-Artibai Development Center), Xemein Avenue 12-A, 48270 Markina, Xemein, Spain;1. Department of Wood Science and Technology, Faculty of Civil Engineering, Shahid Rajaee Teacher Training University, Tehran, Iran;2. Department of Chemical Technologies, Iranian Research Organization for Science and Technology (IROST), P.O. Box 15815-3538, Tehran, Iran;1. Dept. Materials Science and Engineering, IQMAAB, Universidad Carlos III de Madrid, Madrid, Spain;2. Dept. Química, Facultad de Ciencias, Universidad de Navarra, 31080, Pamplona, Spain |
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| Abstract: | This paper provides results from a comprehensive experimental characterization on five silicone-based elastomers used as substrates for mechanobiological studies or in soft biomedical implants. A previous paper was recently published which focused on the large strain deformation behavior of these materials. This second part analyzes their reliability for biomedical applications in terms of changes of deformation behavior with the history of loading (long term cyclic behavior), ability to resist loads in the presence of defects (fracture properties), and cytotoxicity. For the latter, all materials are confirmed to be non-toxic which is a prerequisite for their use in mechanobiological studies or as part of implants and biomedical devices. The response in long term uniaxial tests over 220′000 cycles was characterized and the results indicate general stability of the mechanical response with, for some conditions, softening mechanisms active mainly in the initial phase of the test (50′000 cycles). A critical aspect of elastomer performance and their suitability for application in biomedical devices concerns their fracture properties. The tearing energy varies in a range from brittle (with approximately 80 J/m2 for PDMS Sylgard 184) to tough (with approximately 900 J/m2 for SMI G/G 0.020). |
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| Keywords: | Silicone-based elastomers Biomedical applications Tearing energy Long term cyclic behavior Cytotoxicity |
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