Simultaneous voltammetric determination of acetylsalicylic acid,caffeine and paracetamol in pharmaceutical formulations using screen-printed carbon electrode |
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Authors: | Karla Cortés Juan José Triviño Verónica Arancibia |
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Affiliation: | 1. Pontificia Universidad Católica de Chile, Facultad de Química y de Farmacia, Santiago, 8331150 Chile;2. Universidad de Chile, Facultad de Ciencias Químicas y Farmacéuticas, Departamento de Química Inorgánica y Analítica, Santiago, 8380000 Chile |
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Abstract: | Electrochemical oxidation of Paracetamol (PAR), Acetylsalicylic acid (ASA) and Caffeine (CAF) was investigated employing square wave stripping voltammetry (SWSV) using screen–printed carbon electrodes (SPCE). Determinations were performed in 0.1 mol L−1 BR buffer (pH 2.0) without accumulation step. SWV were obtained by scanning the potential from 0.00 to 1.40 V employing a scan increment of 4 mV, pulse amplitude 25 mV and frequency of 25 Hz. PAR, ASA and CAF presents oxidation signals at 0.45, 1.03 and 1.32 V. The detection limits were 1.2, 1.7 and 1.7 mg L−1, respectively. The method was applied in the PAR-ASA-CAF determination on pharmaceutical formulations. |
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Keywords: | acetylsalicylic acid adsorptive stripping voltammetry boron doped diamond electrode caffeine carbon screen printed electrode paracetamol |
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