A novel method for the determination of diffusion coefficients in amorphous poly(3-hydroxybutyrate) |
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| Institution: | 1. Laboratory of Plastics and Rubber Technology, Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, H-1521 Budapest, P.O. Box 91, Hungary;2. Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, H-1519 Budapest, P.O. Box 286, Hungary;1. Department of Material and Commodity Sciences and Textile Metrology, Lodz University of Technology, 90-924 Lodz, Poland;2. Institute of Applied Computer Science, Lodz University of Technology, 90-924 Lodz, Poland;3. University of Social Sciences, 90-113 Lodz, Poland;1. Department of Railway Engineering, School of Civil Engineering, Central South University, Changsha, Hunan, 410075, China;2. Department of Engineering and Technology, Trelleborg IAVS, Leicester, LE4 2BN, UK;3. Department of Automotive Engineering, Tsinghua University, Beijing, 100084, China;1. Academy of Opto-Electronics, Chinese Academy of Sciences, Beijing 100094, China;2. School of Aeronautic Science and Engineering, Beihang University, Beijing 100191, China;1. Institute of Continuous Media Mechanics UB RAS, Perm, Russia;2. Perm State University, Perm, Russia;3. Leibniz Institute of Polymer Research, Dresden, Germany;1. Polymer Science and Technology Program, Department of Chemistry, Faculty of Science, Mahidol University, Phuttamonthon 4 Road, Salaya, Phuttamonthon District, Nakhon Pathom 73170, Thailand;2. Rubber Technology Research Center, Faculty of Science, Mahidol University, Phuttamonthon 4 Road, Salaya, Phuttamonthon District, Nakhon Pathom 73170, Thailand;3. Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol University, Phuttamonthon 4 Road, Salaya, Phuttamonthon District, Nakhon Pathom 73170, Thailand;4. Center of Sustainable Energy and Green Materials, Faculty of Science, Mahidol University, Phuttamonthon 4 Road, Salaya, Phuttamonthon District, Nakhon Pathom 73170, Thailand |
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| Abstract: | A novel approach is proposed for the determination of the diffusion coefficient of certain drugs in amorphous poly(hydroxybutyrate) (PHB), which can be a reliable alternative to the conventional permeation based measurements. The method requires the preparation of PHB films with various concentrations of the drug and if the latter absorbs in the visible wavelength range, its concentration gradient in the polymer film as well as the time dependence of the latter can be analyzed quantitatively by following changes in color. Color can be converted into concentration with the help of adequate calibration and thus the dependence of additive concentration on space (x) and time (t), i.e. the c(x,t) function, can be determined relatively easily. The fitting of the numerical solution of Fick's second law onto the measured values provides directly the targeted diffusion coefficient. The comparison of diffusion coefficients obtained by the proposed approach to values published in the literature proved that the new method provides reliable results and requires reasonable time and effort at the same time. |
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| Keywords: | PHB film Dissolution Diffusion Concentration gradient Measurement of color Fick's laws |
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