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Gold-dendrimer Nanocomposite Based Electrochemical Sensor for Dopamine
Authors:Dimpo S Sipuka  Prof Omotayo A Arotiba  Tsholofelo I Sebokolodi  Tebogo R Tsekeli  Dr Duduzile Nkosi
Institution:Department of Chemical Sciences, University of Johannesburg, 2028 Doornfontein, Johannesburg, South Africa
Abstract:An electrochemical sensor for dopamine was developed by electrodepositing poly(propylene imine) (PPI) dendrimer and gold nanoparticles (AuNPs) onto a glassy carbon electrode (GCE). Electrochemical characterisation of the sensor was carried out by cyclic voltammetry and electrochemical impedance spectroscopy in ferri/ferrocyanide electrolyte. The nanocomposite electrode (GCE-PPI-AuNPs) showed improved electroactive surface area and electrochemical response over bare GCE. The sensor recorded a detection limit of 0.16 μM over a concentration range of 0.1 μM to 125 μM. The sensor was applied for dopamine detection in human serum samples and in the presence of interfering substances such as ascorbic acid and epinephrine.
Keywords:electrochemical sensor  dopamine  gold nanoparticles  poly (propylene imine) dendrimer  square wave voltammetry
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