Economic Electrochemical Sensors for the Determination of Eszopiclone in Pharmaceutical Formulation with Greenness Profile Assessment |
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| Authors: | Amira F. El-Yazbi Suzy M. Sabry Marwa S. Moneeb Feda A. H. Elgammal Hebatallah M. Essam |
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| Affiliation: | 1. Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry, University of Alexandria, El-Messalah, Alexandria, 21521 Egypt;2. Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt |
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| Abstract: | Electrochemical-ion-selective-sensors offer green, rapid, economic and simple analytical-tool in pharmaceutical industry, control processes, physiological measurements and environmental monitoring. In this study, two sensors were introduced for eszopiclone (EZP) determination in pure-form and in pharmaceutical-dosage-forms using drug-ion-exchanger association complex fabrication technique. Two different ion-exchangers were used and compared, tetrakis (4-chlorophenyl) borate in sensor1 and tetraphenyl borate in sensor 2. Such sensors showed superior performance at pH 3.5 over a wide-range of EZP concentration. The proposed method was also assessed using GAPI and analytical Eco-scale. Low cost, short analysis-time, simplicity and greenness of the proposed sensors allow their use for high-through-put analysis in quality-control laboratories. |
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| Keywords: | Eszopiclone Ion Selective Electrode Tetraphenylborate Tetrakis Nitrophenyl octyl ether Greenness assessment |
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