| 受体酪氨酸激酶抑制剂Dovitinib的合成 |
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| 引用本文： | 喻理德,崔汉峰,王星,袁金斌. 受体酪氨酸激酶抑制剂Dovitinib的合成[J]. 江西师范大学学报(自然科学版), 2013, 0(2): 152-154 |
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| 作者姓名： | 喻理德 崔汉峰 王星 袁金斌 |
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| 作者单位： | 江西中医学院药物中间体合成中心,江西南昌,330004 |
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| 基金项目： | 江西省教育厅青年科学基金(GJJ12538)资助项目 |
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| 摘 要： | 5-氟-2-硝基苯胺经N-甲基哌嗪取代,氢气还原,与3-乙氧基-3-亚氨基丙酸乙酯盐酸盐环合,最后与2-氨基-6-氟苯腈反应得Dovitinib,产物收率为43.6；,液相纯度达99.53；.目标产物结构经氢谱、质谱证实.
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| 关 键 词： | Dovitinib 抗肿瘤药 酪氨酸激酶抑制剂 合成 |
The Synthesis of Tyosine Kinase Inhibitor Dovitinib |
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| YU Li-de,CUI Han-feng,WANG Xing,YUAN Jin-bin. The Synthesis of Tyosine Kinase Inhibitor Dovitinib[J]. Journal of Jiangxi Normal University (Natural Sciences Edition), 2013, 0(2): 152-154 |
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| Authors: | YU Li-de CUI Han-feng WANG Xing YUAN Jin-bin |
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| Affiliation: | (Drug Intermediates Synthesis Center,Jiangxi Chinese Medicine University,Nanchang Jiangxi 330004,China) |
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| Abstract: | By substituting 5-chloro-2-nitroaniline by N-methylpiperazine and reduced eby hydrogen,dovitinib is obtained via two cyclizations.The target product structure is confirmed by hydrogen spectrum,mass spectrometry with yield 43%,and liquid purity to 99.53%. |
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| Keywords: | dovitinib antitumor tyrosine kinase inhibitor synthesis |
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