Inhibitory Effects of Polygoni Multiflori Caulis Extracts on Matrix Metalloproteinase Activities |
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| Authors: | LIU Jun-song. YANG Jin-gang HONG Yuan JIN Feng-hai WANG Ming-cui ZHAO Shu-hua FANG Xue-xun . Key Laboratory of Molecular Enzymology Enzyme Engineering of Ministry of Education Jilin University Changchun P. R. China . College of Life Science Changchun . College of Medicine |
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| Affiliation: | [1]Key Laboratory of Molecular Enzymology and Enzyme Engineering of Ministry of Education, Jilin University, Changchun 130021, P. R. China [2]College of Life Science, Jilin University, Changchun 130012, P. R. China [3]College of Medicine, Jilin University, Changchun 130021, P. R. China [4]Department of Traditional Chinese Medicine, China-Japan Union Hospital Jilin University, Changchun 130033, P. R. China [5]State key Laboratory of Superhard Materials, Jilin University, Changchun 130012, P. R. China |
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| Abstract: | Matrix metalloproteinases(MMPs) play an essential role in development and tissue remodeling of living organisms.However,the overexpression of MMPs has lead to a series of diseases,such as cancer,arthritis,and atherosclerosis;and inhibition of MMPs may have therapeutic benefits.The discovery of MMP inhibitors from herbal has become a prospective event.We showed that the extract of Polygoni multiflori caulis from ethy1 acetate or water(ethy1 acetate extract and water extract) can inhibit the activities of MMPs 9,14,and 16 in a dose-dependent manner and n-buty1 alcohol extract of it can also inhibit these MMPs.Furthermore,we found that n-buty1 alcohol extract and water extract of it influence the cell viability.These discoveries may contribute to the development of MMP inhibitors for the therapy of a variety of pathological conditions. |
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| Keywords: | Matrix metalloproteinases(MMPs) Polygoni multiflori caulis Water extract Cell viability assay |
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