Enantioselective Friedel-Crafts alkylation of indole derivatives catalyzed by new Yb(OTf)3-pyridylalkylamine complexes as chiral Lewis acids |
| |
| Authors: | Grach Guillaume Dinut Aurelia Marque Sylvain Marrot Jérôme Gil Richard Prim Damien |
| |
| Institution: | Université de Versailles-Saint-Quentin, Institut Lavoisier de Versailles UMR CNRS 8180, 45, avenue des états-Unis, 78035 Versailles Cedex, France. |
| |
| Abstract: | New Yb(OTf)(3)-pyridylalkylamine complexes have been employed as chiral Lewis acids in the enantioselective Friedel-Crafts alkylation of indole derivatives with trifluoropyruvates. The influence of the substituents as well as the configuration of the ligands have been studied and allowed us to reach enantiomeric excesses up to 83%. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
