Methionine ligand selectively promotes monofunctional adducts between trans-EE platinum anticancer drug and guanine DNA base |
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| Authors: | Alberto Marta E Russo Nino |
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| Affiliation: | Dipartimento di Chimica, Università della Calabria, 87036 Arcavacata di Rende (CS), Italy. |
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| Abstract: | A detailed study on the reaction mechanism of trans-EE and trans-EE/Met Pt-containing anticancer drugs was carried out in order to rationalize the experimental kinetic data concerning the whole process leading to DNA platination. |
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