Synthesis and thermal behavior of new ambazone complexes with some transitional cations |
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Authors: | Codruţa Şoica Adriana Fuliaş Gabriela Vlase Cristina Dehelean Titus Vlase Ionuţ Ledeţi |
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Affiliation: | 1. Faculty of Pharmacy, University of Medicine and Pharmacy “Victor Babe?”, Eftimie Murgu Square 2, 300041, Timisoara, Romania 2. Research Centre for Thermal Analysis in Environmental Problems, West University of Timisoara, Pestalozzi Street 16, 300115, Timisoara, Romania
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Abstract: | Ambazone is a pharmaceutical compound that possesses antiseptic activity and tested as well for anti-tumor properties. Metal complexes of Zn(II), Fe(III), and Cu(II) containing ambazone as ligand were synthesized using a molar ratio salt:ligand of 1:1, heating the mixture up to 50 °C for 6 h. Coordination compounds were characterized by thin-layer chromatography, FT-IR spectroscopy, elemental analysis, and thermal behavior. The non-isothermal experiments were carried out in order to investigate the thermal degradation process of these complexes and were performed in a dynamic air atmosphere at a heating rate β = 10 °C min?1 from ambient temperature, up to 500 °C. It was revealed that decomposition process is a multistadial one. |
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