Synthesis and Crystal Structure of (7R,8S,9S,12S)-13,14-dehydro-1-(4'-fluorobenzyloxy)-N-methyl-2,13-dimethoxy-12-hydroxymorphinane |
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| Authors: | ZHENG Xing-Liang JIANG Ning-Fei CHEN Shu-Jun ZHAN Xue-Hui JIANG Qing-Feng |
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| Institution: | ZHENG Xing-Liang JIANG Ning-Fei CHEN Shu-Jun ZHAN Xue-Hui JIANG Qing-Feng (Institute of Chemistry and Biological Engineering,Changsha University of Science and Technology,Changsha,Hunan 410076,China) |
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| Abstract: | The title compound (7R,8S,9S,12S)-13,14-dehydro-1-(4-fluorobenzyloxy)-N-methyl-2,13-dimethoxy-12-hydroxymorphinane was synthesized by the reaction of O-4-bromobenzyl-sinomenine with lithium aluminum hydride.Its chemical structure was determined by X-ray single-crystal diffraction.The crystal belongs to triclinic,space group P1 with M r=439.51,a=7.7236(1),b=8.7282(1),c=9.9342(2),α=81.176(1),β=67.43,γ=64.577(1)°,μ=0.76 mm-1,V=558.45(2)3,Z=1,D c=1.307 mg/m 3,F(000)=234 and T=133 K. |
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| Keywords: | synthesis crystal structure sinomenine rheumatoid arthritis |
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