| Synthesis and Crystal Structure of Methyl 3-（5- Bromo-1-ethyl-1H-indole-3-carbonyl）aminopropionate |
| |
| 引用本文： | 李恺平,郑乐,曾向潮,胡芳.Synthesis and Crystal Structure of Methyl 3-（5- Bromo-1-ethyl-1H-indole-3-carbonyl）aminopropionate[J].结构化学,2011,30(7):1044-1048. |
| |
| 作者姓名： | 李恺平 郑乐 曾向潮 胡芳 |
| |
| 作者单位： | Department of Chemistry;Jinan University; |
| |
| 基金项目： | supported by the Natural Science Foundation of Guangdong Province (No.06300581) |
| |
| 摘 要： | Methyl 3-(5-bromo-1-ethyl-1H-indole-3-carbonyl)aminopropionate has been syn-thesized by the acylation of 5-bromo-3-trichloroacetylindole with β-alanine methyl ester,followed by alkylation with ethyl iodide,in 82.6% yield.Its crystal structure was gotten and determined by X-ray diffraction method.The crystal is of monoclinic,space group P2 1 /c with a=11.7927(8),b=14.9342(8),c=9.0060(5),β=101.558(6)°,V=1553.93(16)3,Z=4,D c=1.510 g/cm 3,λ=0.71073,μ(MoKα)=2.656 mm-1,M r=353.22 and F(000)=720.The structure was refined to R=0.0401 and wR=0.0825 for 1704 observed reflections with I > 2σ(I).In the crystal structure,intermolecular N(2)-H(2)···O(1) hydrogen bond and weak intermolecular bonds (C(1)-H(1) O(1) and C(10)-H(10B) O(2)) are formed,and π-π stacking also exists.
|
| 关 键 词： | 晶体结构 合成 乙基 吲哚 羰基 溴 烷基化反应 射线衍射 |
Synthesis and Crystal Structure of Methyl 3-(5-Bromo-1-ethyl-1H-indole-3-carbonyl)aminopropionate |
| |
| LI Kai-Ping,ZHENG Le,ZENG Xiang-Chao,HU Fang.Synthesis and Crystal Structure of Methyl 3-(5-Bromo-1-ethyl-1H-indole-3-carbonyl)aminopropionate[J].Chinese Journal of Structural Chemistry,2011,30(7):1044-1048. |
| |
| Authors: | LI Kai-Ping ZHENG Le ZENG Xiang-Chao HU Fang |
| |
| Institution: | Department of Chemistry, Jinan University, Guangzhou 510632, China |
| |
| Abstract: | Methyl 3-(5-bromo-1-ethyl-1H-indole-3-carbonyl)aminopropionate has been syn-thesized by the acylation of 5-bromo-3-trichloroacetylindole with β-alanine methyl ester, followed by alkylation with ethyl iodide, in 82.6％ yield. Its crystal structure was gotten and determined by Ⅹ-ray diffraction method. The crystal is of monoclinic, space group P2<,1>/c with a = 11.7927(8), b =14.9342(8), c=9.0060(5) A, β= 101.558(6)°, V= 1553.93(16) A<,'3>,Z=4, Dc=1.510 g/cm<'3>,λ=0.71073 A,μ(MoKa) = 2.656 mm<'-1>, Mr = 353.22 and F(000) = 720. The structure was refined to R =0.0401 and wR = 0.0825 for 1704 observed reflections with Ⅰ > 20(Ⅰ). In the crystal structure,intermolecular N(2)-H(2)…O(1) hydrogen bond and weak intermolecular bonds (C(1)-H(1)…O(1)and C(10)-H(10B)…O(2)) are formed, and π-π stacking also exists. |
| |
| Keywords: | methyl 3-(5-bromo-1-ethyl-1H-indole-3-carbonyl)aminopropionate indole synthesis crystal structure |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
