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| Anti-tumor Metastasis and Crystal Structure of N1（1,3,4-Thiadiazole-2-yl）-N3-m-chlorobenzoyl-urea | |
| 引用本文： | 邹霞娟,章士伟,刘莹,刘振明,高军卫,宋前流,潘燕,张剑钊,李学军.Anti-tumor Metastasis and Crystal Structure of N1（1,3,4-Thiadiazole-2-yl）-N3-m-chlorobenzoyl-urea[J].结构化学,2011,30(7):1001-1005. |
| 作者姓名： | 邹霞娟 章士伟 刘莹 刘振明 高军卫 宋前流 潘燕 张剑钊 李学军 |
| 作者单位： | Proteomics Laboratory;Medical and Healthy Analytical Center;Peking University;State Key Laboratory for Structural Chemistry of Unstable and Stable Species;College of Chemistry and Molecular Engineering;School of Basic Medical Sciences; |
| 基金项目： | supported by 863 high technology program (No.2001AA23561) |
| 摘 要： | The title compound N 1-(1,3,4-thiadiazole-2-yl)-N 3-m-chlorobenzoyl-urea (C 9 H 7 N 4 OSCl,M r=254.70) was prepared by the reaction of m-chlorophenyl isocyanate with 2-amino-1,3,4-thiadiazole in dry acetonitrile.The effect of the title compound on tumor metastasis was analyzed by Lewis-lung-carcinoma model.The bioassay showed that the title compound significantly reduced the number of lung metastasis.The crystal structure has been determined by X-ray diffraction.The crystal belongs to the monoclinic system,space group P2 1 /c with a=11.565(2),b=9.5616(19),c=10.221(2),β=111.75(3)°,Z=4,V=1049.8(4)3,D c=1.612 Mg/m 3,F(000)=520,μ(MoKa)=0.544 mm-1,R=0.0468 and wR=0.0922 for 1236 observed reflections (I > 2σ(I)). |
| 关 键 词： | 晶体结构 肿瘤转移 噻二唑 氯苯 尿素 标题化合物 异氰酸酯 生物测定 |
Anti-tumor Metastasis and Crystal Structure of N~1-(1,3,4-Thiadiazole-2-yl)-N~3-m-chlorobenzoyl-urea |
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| ZOU Xia-Juan,ZHANG Shi-Wei,LIU Ying,LIU Zheng-Ming,GAO Jun-Wei,SONG Qian-Liu,PAN Yan,ZHANG Jian-Zhao,LI Xue-Jun.Anti-tumor Metastasis and Crystal Structure of N~1-(1,3,4-Thiadiazole-2-yl)-N~3-m-chlorobenzoyl-urea[J].Chinese Journal of Structural Chemistry,2011,30(7):1001-1005. | |
| Authors: | ZOU Xia-Juan ZHANG Shi-Wei LIU Ying LIU Zheng-Ming GAO Jun-Wei SONG Qian-Liu PAN Yan ZHANG Jian-Zhao LI Xue-Jun |
| Institution: | 1. Proteomics Laboratory, Medical and Healthy Analytical Center, Peking University, Beijing 100191, China 2. State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China 3. School of Basic Medical Sciences, Peking University, Belting 100191, China |
| Abstract: | The title compound N 1-(1,3,4-thiadiazole-2-yl)-N 3-m-chlorobenzoyl-urea (C 9 H 7 N 4 OSCl,M r=254.70) was prepared by the reaction of m-chlorophenyl isocyanate with 2-amino-1,3,4-thiadiazole in dry acetonitrile.The effect of the title compound on tumor metastasis was analyzed by Lewis-lung-carcinoma model.The bioassay showed that the title compound significantly reduced the number of lung metastasis.The crystal structure has been determined by X-ray diffraction.The crystal belongs to the monoclinic system,... |
| Keywords: | crystal structure anti-tumor metastasis 2-amino-1 3 4-thiadiazole derivatives Lewis-lung-carcinoma model synthesis |
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