| 淫羊藿苷对去卵巢快速老化小鼠(SAMP8)学习记忆及皮层氧化应激的影响 |
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| 引用本文： | 刘东华,吴满刚,毕明刚,杜冠华. 淫羊藿苷对去卵巢快速老化小鼠(SAMP8)学习记忆及皮层氧化应激的影响[J]. 压电与声光, 2010, 0(6) |
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| 作者姓名： | 刘东华 吴满刚 毕明刚 杜冠华 |
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| 作者单位： | 哈尔滨商业大学生命科学与环境科学研究中心;中国医学科学院药用植物研究所;中国医学科学院药物研究所; |
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| 基金项目： | 国家自然科学基金项目(30772750);;“重大新药创制”科技重大专项(2009ZX09301-003)~~ |
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| 摘 要： | 目的研究淫羊藿苷(ICA)对去卵巢雌性快速老化模型小鼠(SAMP8)学习记忆能力及抗氧化能力的影响。方法本实验以10月龄去卵巢雌性SAMP8小鼠为模型,以同月龄抗快速老化小鼠(SAMR1)为正常对照,以SAMP8假手术作为对照。实验共分为SAMR1组、SAMP8假手术组、SAMP8手术组、多奈哌齐组、己烯雌酚组、ICA75mg/kg组、ICA150mg/kg组7组。灌胃给药8周,通过Morris水迷宫检验ICA对SAMR1和SAMP8学习记忆能力的影响;测定大脑皮层中NO、MDA、SOD、GSH-Px活性。结果ICA150mg/kg、75mg/kg可明显改善OVX SAMP8定位航行潜伏期(P<0.05),提高空间探索能力,平台象限停留时间为ICA150mg/kg45.88±2.98s,ICA75mg/kg40.26±3.66s,OVX SAMP817.13±3.73s(P<0.05);可明显提高大脑皮层内SOD及GSH-Px活性(P<0.05),显著降低MDA及NO的水平(P<0.05)。结论ICA可以改善OVX SAMP8的学习记忆能力,可显著提高OVX SAMP8抗氧化能力。
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| 关 键 词： | 淫羊藿苷 快速老化小鼠 学习 记忆 抗氧化 |
Effect of Icariin on learning and memory, cortex oxidative stress in ovarietomized senescence-accelerated prone/8 female mice |
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| LIU Dong-hu,WU Man-gang,BI Ming-gang,DU Guan-hua Life,Environment Science Research Center,Harbin University of Commerce,Harbin,China. Effect of Icariin on learning and memory, cortex oxidative stress in ovarietomized senescence-accelerated prone/8 female mice[J]. Piezoelectrics & Acoustooptics, 2010, 0(6) |
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| Authors: | LIU Dong-hu WU Man-gang BI Ming-gang DU Guan-hua Life Environment Science Research Center Harbin University of Commerce Harbin China |
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| Affiliation: | LIU Dong-hua1,WU Man-gang1,BI Ming-gang2,DU Guan-hua3 1 Life , Environment Science Research Center,Harbin University of Commerce,Harbin 150076,China,2Institute of Medicinal Plant Development,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100193,3Institute of Materia Medica,Beijing 100050 |
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| Abstract: | Objective To investigate the effects of icariin(ICA)on learning and memory,and antioxidative ability of ovariectomized senescence accelerated prone/8 female mice.Methods Female mice with ovariectomized senescence-accelerated prone/8(SAP8)at the age of 10 months were divided into model group,normal group and sham operation group.Experimental group was further divided into senescence-accelerated resistant mouse1(SAMR1)group,sham operation group,SAP8 group,donepezil group,stilbestrol group,ICA75mg/kg group and... |
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| Keywords: | Icariin Senescence Accelerated Mouse Prone/8 Learning Memory Antioxydant |
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