Synthesis and immunomodulatory activity of some novel amino acid germinates |
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Authors: | A. M. Badawi A. A. Hafiz |
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Affiliation: | 1. Applied Surfactant Laboratory, Egyptian Petroleum Research Institute (EPRI) Nasr City, Cairo, Egypt
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Abstract: | Amino acid germanate compounds are synthesized by the chemical reaction of germanium dioxide with a selected amino acid in the presence of an alkali medium at a suitable elevated temperature. Amino acids included in the novel synthesis include histidine, methionine and glutathione. The study evaluated their effects on induction of interleukin-12 and interferon-γl in Swiss albino Webster rats. The new germanium compounds, especially bis-methionino germanate, are considered as good interferon inducer that significantly enhance the immunologic function. |
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