Ca(HSO4)2 mediated conversion of alcohols into N-substituted amides under heterogeneous conditions: A modified Ritter reaction |
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| Authors: | K Niknam M A Zolfigol T Sadabadi |
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| Institution: | 1. Chemistry Department, Faculty of Sciences, Persian Gulf University, Bushehr, 75169, Iran
2. Faculty of Chemistry, Bu-Ali Sina University, Hamadan, 65174, Iran
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| Abstract: | Tertiary, secondary, and benzylic alcohols react efficiently with nitriles in the presence of the catalyst calcium hydrogen sulfate, Ca(HSO4)2, to produce amides in high yields. In this study, a modified Ritter reaction using this solid acid catalyst is found to be an environmentally safe method for converting 2,6-bis(hydroxymethyl)-4-halo anisole into the corresponding diamides in CH3CN. |
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