2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate as an efficient coupling reagent for the amidation and phenylhydrazation of carboxylic acids at room temperature |
| |
Authors: | S. Balalaie M. Mahdidoust R. Eshaghi-Najafabadi |
| |
Affiliation: | 1. Peptide Chemistry Research Group, K.N. Toosi University of Technology, P.O. Box 15875-4416, Tehran, Iran
|
| |
Abstract: | The synthesis of amides and phenylhydrazides from the reaction of corresponding carboxylic acids with primary aliphatic, aromatic amines or phenylhydrazine in the presence of triethylamine or diisopropylethyl amine as a base using 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) proceeds smoothly under mild conditions to afford the corresponding amides or phenylhydrazides in good to high yields in ethyl acetate at room temperature. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|