Palladium(II)-catalyzed synthesis of functionalized indenes from o-alkynylbenzylidene ketones |
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| Authors: | Zhou Feng Han Xiuling Lu Xiyan |
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| Institution: | State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China. |
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| Abstract: | An efficient method for the synthesis of functionalized indenes from o-alkynylbenzylidene ketones under palladium(II) catalysis was developed. The reaction is initiated by trans-nucleopalladation of alkynes, followed by conjugate addition and quenched by protonolysis of the carbon-palladium bond. With acetate and halide ions as nucleophiles, 3-acetoxy- and 3-halogen-substituted indenes could be obtained in high yields. |
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