Selective synthesis of gem-chlorofluorinated nitrogen-containing derivatives after superelectrophilic activation in superacid HF/SbF5 |
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Authors: | Liu Fei Martin-Mingot Agnès Jouannetaud Marie-Paule Bachmann Christian Frapper Gilles Zunino Fabien Thibaudeau Sébastien |
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Institution: | Laboratoire Synthèse et Réactivité des Substances Naturelles, UMR 6514, 40 avenue du Recteur Pineau, F-86022 Poitiers Cedex, France. |
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Abstract: | The first direct selective synthesis of novel gem-chlorofluorinated nitrogen-containing building blocks in superacid is reported. The dramatic role of the chlorine atom on the reaction is shown by in situ NMR experiments and allows the involvement of a novel original superelectrophilic activation process in superacid HF/SbF(5) to be postulated. |
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