(2S,5S)-Pyrrolidine-2,5-dicarboxylic acid,an efficient chiral organocatalyst for direct aldol reactions |
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| Institution: | 1. Institute of Fine Chemicals, Lab of Advanced Materials, East China University of Science and Technology, Shanghai 200237, China;2. State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China;1. EntreChem, SL, Edificio Científico Tecnológico, Campus El Cristo, 33006 Oviedo, Spain;2. Departamento de Química Orgánica e Inorgánica, Universidad de Oviedo, 33071 Oviedo, Spain;1. Department of Physics, Faculty of Arts and Sciences, Kastamonu University, Kuzeykent, 37100 Kastamonu, Turkey;2. Department of Physics, Faculty of Science, Gazi University, Teknikokullar, 06500 Ankara, Turkey |
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| Abstract: | Enantioselective aldol reaction of ketones with aldehydes catalyzed by (2S,5S)-pyrrolidine-2,5-dicarboxylic acid in the presence of an equal molar amount of Et3N was described. By using the new chiral organocatalyst, the direct aldol condensation products were obtained in reasonable yields and up to 90% ee. |
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