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Enantioselective intramolecular [2+2+2] cycloaddition of triynes for the synthesis of atropisomeric chiral ortho-diarylbenzene derivatives
Affiliation:1. Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong;2. Department of Chemistry, Faculty of Science, Kyoto University, Japan;1. School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150080, China;2. Department of Chemistry, South University of Science and Technology of China, Shenzhen 518055, China;1. Department of Chemistry, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto 860-8555, Japan;2. Priority Organization for Innovation and Excellence, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto 860-8555, Japan;3. Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga, Japan;1. Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou 350207, China;2. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore;3. Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Jurong Island, Singapore;1. Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, China;2. Zhuhai Fudan Innovation Institute, Zhuhai 519000, China;3. School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China
Abstract:An iridium-chiral diphosphine complex was used to catalyze an enantioselective [2+2+2] cycloaddition of oxygen- and nitrogen-bridged triynes with ortho-substituted aryl groups on their termini. ortho-Diarylbenzenes with atropisomeric chiralities were obtained in high yield and enantiomeric excess.
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