Application of chiral ionic liquids in the copper catalyzed enantioselective 1,4-addition of diethylzinc to enones |
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| Institution: | 1. Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China;2. Institute of Human Virology, Sun Yat-sen University, Guangzhou 510080, PR China;3. School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530001, PR China;1. Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia;2. Department of Physics, University College of Engineering, Anna University Constituent College, Nagercoil, Tamil Nadu 629 004, India;3. Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India;4. Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia;5. Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, Jeddah 21589, Saudi Arabia |
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| Abstract: | Copper catalyzed enantioselective addition of diethylzinc to various enones has been achieved in the presence of a new class of chiral ionic liquid (ChirILs) derived from α-pinene. This first study on the application of ChirILs for the title reaction shows that the chiral reaction medium has a significant influence on chiral induction. |
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