Chiral separation of amino acids using a chiral crown ether by impregnation on a polymeric support and monoamine modified silica gel |
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| Institution: | 1. University of Dokuz Eylül, Faculty of Science, Department of Chemistry, 35160 Buca, İzmir, Turkey;2. University of Dicle, Faculty of Science, Department of Chemistry, 21280 Diyarbakır, Turkey;1. Key Lab of Mesoscopic Chemistry of MOE, Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China;2. School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210097, China;1. Department of Chemistry, Amasya University, 05100 Amasya, Turkey;2. Department of Chemistry, Ankara University, 06100 Ankara, Turkey;3. Department of Physics, Hacettepe University, 06800 Ankara, Turkey;4. Department of Biology, Gazi University, 06500 Ankara, Turkey;1. Laboratory of Organic Chemistry, Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece;2. GlaxoSmithKline, 1250 South Collegeville Road, P.O. Box 5089, Collegeville, PA 19426-0989, USA;3. Institute of Chemistry, Environmental Protection and Biotechnology, Jan Długosz University in Częstochowa, 42-201 Częstochowa, Poland;4. Department of Heteroorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 90-363 Łódz, Poland;5. The School of Chemistry, The University of Manchester, Manchester M13 9PL, UK |
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| Abstract: | A chiral monoaza-15-crown-5 ether derivative was prepared from l-Leucinol and used as a chiral stationary phase. The new chiral stationary phases CSP-1 and CSP-2 were employed in separating the enantiomers of the sodium and potassium salts of amino acids. The sodium and potassium salt of the d-enantiomers of all amino acids (PhyAlaNa, PhyAlaK and PhyGlyNa, PhyGlyK, and TrpNa, TrpK) show higher selectivity than the l-enantiomers for both CSP-1 and CSP-2. |
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