Chemoenzymatic syntheses of novel ligands derived from trans-cyclohexane-1,2-diamine: application in the enantioselective addition of diethylzinc to aromatic aldehydes |
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| Institution: | 1. Department of Chemistry, Faculty of Science, University of Kurdistan, 66177-15175 Sanandaj, Iran;2. Nanotechnology and Water Sustainability Research (NanoWS) Unit, College of Science, Engineering and Technology, University of South Africa, Johannesburg 1709, South Africa |
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| Abstract: | Enantiopure (1R,2R)-cyclohexane-1,2-diamine derivatives, easily prepared from the corresponding (±)-trans-2-dialkylaminocyclohexanols through a chemoenzymatic route, have been employed as ligands in the enantioselective addition of diethylzinc to aromatic aldehydes. Of all the ligands tested, C2-symmetric bisaminoamides derived from pyridine-2,6-dicarboxylic acid proved to be the most efficient. |
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