Effects of organic solvents and ionic liquids on the aminolysis of (RS)-methyl mandelate catalyzed by lipases |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, University Malaya, Kuala Lumpur 50603, Malaysia;2. University Malaya Center for Ionic Liquids (UMCiL), Universiti Malaya, Kuala Lumpur 50603, Malaysia;3. International Institute for Halal Research and Training (INHART), International Islamic University Malaysia, P.O Box 10, Kuala Lumpur 50728, Malaysia;4. Department of Chemical Engineering, Faculty of Engineering, University Malaya, Kuala Lumpur 50603, Malaysia;5. Chemical Engineering Program, Faculty of Engineering and Technology, Muscat University, P.O. Box 550 P.C. 130, Muscat, Oman;6. Federal University Lafia, PMB 146, Lafia, Nasarawa, Nigeria |
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| Abstract: | The enzymatic resolution of (RS)-methyl mandelate with n-butylamine using lipases in organic solvents (n-hexane, tert-butanol, and chloroform) and ionic liquids [BMIm][BF4] and [BMIm][PF6] is reported. The amide configuration is dependent on the organic solvent. When using mixtures of chloroform or tert-butanol/ionic liquids (10:1 v/v) with CAL-B as the catalyst, the amides were obtained in high enantiomeric excess (eep >99% and E >200). |
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