A stereoselective synthetic approach to (2S,3R)-N-(1′,1′-dimethyl-2′,3′-epoxypropyl)-3-hydroxytryptophan,a component of cyclomarin A |
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| Institution: | 1. Department of Experimental Oncology, European Institute of Oncology, Milan, Italy;2. Molecular Medicine Program, Department of Experimental Oncology, European Institute of Oncology, Milan, Italy |
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| Abstract: | A stereoselective synthetic approach to (2S,3R)-N-(1′,1′-dimethyl-2′,3′-epoxypropyl)-3-hydroxytryptophan an amino acid contained in cyclomarin A was accomplished. The synthesis is based on a diastereoselective addition of an indole Grignard into a chiral serine aldehyde equivalent. |
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