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Age-related declines in a two-day reference memory task are associated with changes in NMDA receptor subunits in mice |
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| Authors: | Kathy R Magnusson Brandi Scruggs Xue Zhao Rebecca Hammersmark |
| Institution: | (1) Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, 97331 Corvallis, OR, USA;(2) Department of Biological Sciences, University of Idaho, College of Science, 83844 Moscow, ID, USA;(3) Behavioral testing performed at: Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Program in Molecular, Cellular, and Integrative Neurosciences and Department of Psychology, Colorado State University, 80523 Fort Collins, CO, USA;(4) Department of Psychology, Worcester State College, 01602-2597 Worcester, MA, USA |
| Abstract: | BackgroundC57BL/6 mice show a relationship during aging between NMDA receptor expression and spatial reference memory performance in a 12-day task. The present study was designed to determine if age-related deficits could be detected with a shorter testing protocol and whether these deficits showed a relationship with NMDA receptors. Mice were trained in a reference memory task for two days in a Morris water maze. Cued testing was performed either after or prior to reference memory testing. Crude synaptosomes were prepared from prefrontal/frontal cortex and hippocampus of the mice that underwent reference memory testing first. NMDA receptor subunit and syntaxin proteins were analyzed with Western blotting. |
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