Four new chamigrane sesquiterpenoids from the opistobranch mollusk <Emphasis Type="Italic">Aplysia dactylomela</Emphasis> |
| |
| Authors: | L K Shubina S N Fedorov A I Kalinovskiy A S Dmitrenok J O Jin M G Song J Y Kwak V A Stonika |
| |
| Institution: | (1) State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China;(2) Graduate School of Chinese Academy of Sciences, Beijing, 100039, China; |
| |
| Abstract: | Four new chamigrane sesquiterpenoids, (6S,10S)-10-bromo-3,11,11-trimethyl-7-methylidenespiro5.5]undec-2-ene-4-one, (4S,6S,10S)-10-bromo-3,11,11-trimethyl-7-methylidenespiro5.5]undec-2-ene-4-ol, (3R,4S,6S,10R)-10-bromo-3,11,11-trimethyl-7-methylidenespiro5.5]undecane-3,4-diol, and (6S,7S,11R)-2-chloro-3,7,11-trimethyl-10-methylidenespiro5.5]undec-2-ene-7-ol, were isolated from the sea hare Aplysia dactylomela. The chemical structures of new compounds were established by NMR spectroscopy and mass spectrometry. The cytotoxic activity
of some of the obtained compounds against promyelocytic HL-60 and monocytic THP-1 leukemia cells was demonstrated. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
